The most Truthful list of all Vaccines Published to date including All Official Ingredients

The most Truthful list of all Vaccines Published to date including All Official Ingredients

Amanda Mary (Mary)

We have listed vaccine ingredients (substances that appear in the final vaccine product), process ingredients (substances used to create the vaccine that may or may not appear in the final vaccine product), and growth mediums (the substances vaccines are grown in) for 31 vaccines commonly recommended by the Food & Drug Administration (FDA) and the Centers for Disease Control (CDC.) Controversial products used to make vaccines: African Green Monkey (Vero) cells, aluminum, cow products, Cocker Spaniel cells, formaldehyde, human fetal lung tissue cells, insect products, and mouse brains.

Though not listed, each vaccine contains strains of the virus being vaccinated against. Each vaccine entry links to the manufacturer’s package insert that contains information about dosage, ingredient quantity, and how the vaccine is made. Some vaccines, like influenza vaccines, are modified frequently and you may wish to consult the package inserts online and your doctor for the most current information.

  • VACCINES AND INGREDIENTS
  1. Adenovirus
  2. Anthrax
  3. BCG (tuberculosis)
  4. DT (diphtheria & tetanus)
  5. DTap (diptheria, tetanus, & pertussis)
  6. DTap-IPV (diptheria, tetanus, pertussis, & polio)
  7. DTap-HepB-IPV (diptheria, tetanus, pertussis, hepatitis B, & polio)
  8. DTap-IPV/Hib (diptheria, tetanus, pertussis, polio, & haemophilus influenzae type B)
  9. Hib (haemophilus influenzae type B)
  10. Hib/Hep B (haemophilus influenzae type B & hepatitis B)
  11. Hep A (hepatitis A)

12.Hep B (hepatitis B)

  1. Hep A/Hep B (hepatitis A & hepatitis B)
  2. HPV (human papillomavirus)
  3. Influenza 16. Japanese Encephalitis
  4. Measles
  5. Meningococcal
  6. MMR (measles, mumps, & rubella)
  7. Pneumococcal
  8. Polio
  9. Rabies
  10. Rotavirus
  11. Rubella
  12. Smallpox
  13. TD (tetanus & diphtheria)
  14. Tdap (tetanus, diphtheria, & pertussis)
  15. Typhoid
  16. Varicella (chickenpox)
  17. Yellow Fever
  18. Zoster (shingles)
1. Adenovirus Vaccine
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Adenovirus Type 4 and Type 7 Vaccine, Live, Oral Barr Labs/Teva Pharmaceuticals (under contract with US Army)/Mar. 2011 human-diploid fibroblast cell cultures (WI-38), Dulbecco’s Modified Eagle’s Medium, fetal bovine serum, sodium bicarbonate sucrose, D-mannose, D-fructose, dextrose, potassium phosphate, plasdone C, anhydrous lactose, micro crystalline cellulose, polacrilin potassium, magnesium stearate, cellulose acetate phthalate, alcohol, acetone, castor oil, FD&C Yellow #6 aluminum lake dye, human serum albumin
2. Anthrax Vaccine
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Anthrax Vaccine Absorbed/

Biothrax

Emergent Biosolutions/Dec. 2008 amino acids, vitamins, inorganic salts and sugars aluminum hydroxide, benzethonium chloride, formaldehyde
3. BCG Vaccine(tuberculosis)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
BCG Live/Tice BCG Organon Teknika Corp./Feb. 2009 glycerin, asparagine, citric acid, potassium phosphate, magnesium sulfate, iron ammonium citrate lactose, saline
4. DT Vaccine(diphtheria & tetanus)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Diphtheria and Tetanus Toxoids Absorbed Sanofi Pasteur, Ltd./Dec. 2005 peptone, bovine extract, modified Mueller and Miller medium aluminum sulfate, formaldehyde, thimerosal (trace)
5. DTap Vaccine(diphtheria, tetanus, & pertussis)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Diphtheria and Tetanus Toxoids and Accellular Pertussis Vaccine Absorbed/Daptacel Sanofi Pasteur, Ltd./July 2011 Stainer-Scholte medium, modified Mueller’s growth medium, modified Mueller-Miller casamino acid medium (without beef heart infusion), casamino acids, dimethyl-beta-cyclodextrin, aluminum sulfate, aluminum phosphate aluminum phosphate, formaldehyde, glutaraldehyde, 2-Phenoxyethanol
Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Absorbed/Infanrix GlaxoSmithKline Biologicals/Nov. 2011 formaldehyde, glutaraldehyde, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid medium aluminum hydroxide, polysorbate 80, sodium chloride, formaldehyde
Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Absorbed/Tripedia Sanofi Pasteur, Inc./

Dec. 2005

sodium phosphate, peptone-based medium, bovine extract (US sourced), formaldehyde, ammonium sulfate, aluminum potassium sulfate, modified Mueller and Miller medium, modified Stainer-Scholte medium, isotonic sodium, chloride solution, sodium phosphate thimerosal (trace), gelatin, polysorbate 80 (Tween 80), formaldehyde, aluminum
6. DTap-IPV Vaccine(diphtheria, tetanus, pertussis, & polio)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine/Kinrix GlaxoSmithKline Biologicals/Nov. 2011 formaldehyde, glutaraldehyde, aluminum hydroxide, Vero cells, calf serum, lactalbumin hydrolysate, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid medium polysorbate 80 (Tween 80), neomycin sulfate, polymyxin B, aluminum hydroxide, sodium chloride, formaldehyde
7. DTap-HepB-IPV Vaccine(diphtheria, tetanus, pertussis, hepatitis B, & polio)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Hepatitis B (Recombinant) and Inactivated Poliovirus Vaccine Combined/Pediarix GlaxoSmithKline Biologicals/Nov. 2011 formaldehyde, gluteraldehyde, aluminum hydroxide, aluminum phosphate, lactalbumin hydrolysate, calf serum, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid medium, Vero cells polysorbate 80 (Tween 80), neomycin sulfate, polymyxin B, yeast protein, aluminum salts, sodium chloride, formaldehyde
8. DTap-IPV/Hib Vaccine(diphtheria, tetanus, pertussis, polio, & haemophilus influenzae type B)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate) Vaccine/Pentacel Sanofi Pasteur, Inc./July 2011 aluminum phosphate, formaldehyde, gutaraldehyde, 2-phenoxethanol, Mueller’s Growth Medium, Mueller-Miller casamino acid medium (without beef heart infusion), Stainer-Scholte medium, casamino acids, dimethyl-beta-cyclodextrin), MRC-5 cells, CMRL 1969 medium (supplemented with calf serum), ammonium sulfate, water polysorbate 80, bovine serum albumin, neomycin, polymyxin B sulfate, aluminum phosphate, formaldehyde, 2-phenoxethanol
9. Hib Vaccine(haemophilus influenzae type B)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate)/ActHIB Sanofi Pasteur, Inc./May 2009 ammonium sulfate, formalin, Modified Mueller and Miller medium, saline diluent, formaldehyde sucrose, purified capsular polysaccharide
Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate)/Hiberix GlaxoSmithKline Biologicals/Dec. 2010 formaldehyde, synthetic medium, semi-synthetic medium lactose, sodium chloride, formaldehyde, purified capsular polysaccharide
Haemophilus B Conjugate Vaccine (Meningococcal Protein Conjugate)/Liquid PedvaxHIB Merck Sharp & Dohme Corp./Dec. 2010 complex fermentation media, ethanol amorphous aluminum hydroxphosphate sulfate, sodium chloride
10. Hib/Hep B Vaccine(haemophilus influenzae type B & hepatitis B)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Haemophilus b Conjugate (Meningococcal Protein Conjugate) and Hepatitis B (Recombinant) Vaccine/COMVAX Merck & Co., Inc./Dec. 2010 yeast (vaccine contains no detectable yeast DNA), nicotinamide adenine dinucleotide, hemin chloride, soy peptone, dextrose, mineral salts, amino acids, formaldehyde, potassium aluminum sulfate, amorphous aluminum hydroxyphosphate sulfate, sodium borate aluminum hydroxyphosphate sulphate, sodium chloride, formaldehyde
11. Hep A Vaccine(hepatitis A)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Hepatitis A Vaccine, Inactivated/Havrix GlaxoSmithKline Biologicals/July 2011 MRC-5 cells, formaldehyde aluminum hydroxide, amino acid supplement, polysorbate 20, formalin, neomycin sulfate, phosphate buffered saline, residual MRC-5 cellular proteins, aminoglycoside antibiotic
Hepatitis A Vaccine, Inactivated/VAQTA Merck & Co., Inc./Dec. 2010 amorphous aluminum hydroxyphosphate sulfate, formaldehyde, neomycin, MRC-5 fibroblasts bovine albumin, sodium borate, formaldehyde, non-viral proteins, sodium chloride, neomycin
12. Hep B Vaccine(hepatitis B)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Hepatitis B Vaccine (Recombinant)/Engerix-B GlaxoSmithKline Biologicals/Oct. 2011 aluminum hydroxide, yeast protein, phosphate buffers, sodium chloride, disodium phosphate, dihydrate, sodium dihydrogen
Hepatitis B Vaccine (Recombinant)/Recombivax Merck & Co., Inc./July 2011 yeast protein, soy peptone, dextrose, amino acids, mineral salts, potassium aluminum sulfate, amorphous aluminum hydroxyphosphate sulfate, formaldehyde formaldehyde, yeast protein
13. Hep A/Hep B Vaccine(hepatitis A & hepatitis B)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Hepatitis A Inactivated & Hepatitis B (Recombinant) Vaccine/Twinrix GlaxoSmithKline Biologicals/Nov. 2011 yeast protein, aluminum phosphate, aluminum hydroxide, amino acids, phosphate buffer, polysorbate 20, MRC-5 cells, formaldehyde, sodium chloride neomycin sulfate, MRC-5 cell proteins, formaldehyde, yeast protein, water
14. HPV Vaccine(human papillomavirus)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant/Cervarix GlaxoSmithKline Biologicals/July 2011 vitamins, amino acids, lipids, mineral salts, aluminum (as hydroxide salt), sodium dihydrogen phosphate dehydrate insect cell and viral protein, sodium chloride, water, aluminum hydroxide, bacterial cell protein
Human Papillomavirus Quadrivalent (Types 6, 11, 16, 18) Vaccine, Recombinant/Gardasil Merck & Co., Inc./Mar. 2011 yeast protein, vitamins, amino acids, mineral salts, carbohydrates, amorphous aluminum hydroxyphosphate sulfate, aluminum-containing adjuvant L-histidine, polysorbate 80, sodium borate, amorphous aluminum hydroxyphosphate sulfate adjuvant, sodium chloride, yeast protein, water
15. Influenza Vaccine(Flu)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Influenza Virus Vaccine/Afluria CSL Limited/Apr. 2013 beta-propiolactone, sodium taurodeoxycholate, allantoic fluid of embryonated chicken eggs, sucrose density agent, phosphate buffered isotonic solution thimerosol (multi-dose vials only), monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, neomycin sulfate, polymyxin B, ovalbumin, mercury, sodium, chloride, beta-propiolacton
Influenza Virus Vaccine/Agriflu Novartis Vaccines and Diagnostics, Inc./Feb. 21, 2013 kanamycin, neomycin sulfate, cetyltrimethylammonium bromide, allantoic cavity of embryonated hens’ eggs formaldehyde, egg protein, polysorbate 80, CTAB, neomycin, kanmycin
Influenza Virus VaccineFluarix/ Quadrivalent GlaxoSmithKline Biologicals/May 2013 embryonated chicken eggs, sodium phosphate-buffered isotonic sodium chloride solution, sodium deoxycholate, formaldehyde octoxynol-10 (Triton X-100), a-tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, hydrocortisone, formaldehyde, sodium deoxycholate
Influenza Vaccine/Flublok Protein Sciences Corporation/Oct. 2013 HA insect cell (fall armyworm, Spodoptera frugiperda) proteins, lipids, vitamins, amino acids, mineral salts sodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, polysorbate 20 (Tween 20), host cell proteins, baculovirus, Triton X-100
Influenza Virus Vaccine/Flucelvax Novartis Vaccines and Diagnostics Limited/Feb. 2013 Madin Darby Canine Kidney (MDCK) cells, B-propiolactone, cetyltrimethylammonium bromide residual MDCK cell protein, other cell proteins, MDCK cell DNA, polysorbate 80, cetyltrimethylammonium bromide, B-propiolactone
Influenza Virus Vaccine/FluLaval ID Biomedical Corporation of Quebec/2013-2014 allantoic cavity of embryonated hens’ eggs, formaldehyde, sodium deocycholate phosphate-buffered saline solution, thimerosal, ovalbumin, formaldehyde, sodium deoxycholate
Influenza Vaccine Live, Intranasal/FluMist Quadrivalent MedImmune, LLC/2012-2014 SPF (specific pathogen-free) eggs, stabilizing buffer monosodium glutamate, hydrolyzed porcine gelatin, arginine, sucrose, dibasic potassium phosphate, monobasic potassium phosphate, ovalbumin, gentamicin sulfate, ethylenediaminetetraacetic acid (EDTA)
Influenza Virus VaccineFluvirin Novartis Vaccines and Diagnostics Limited/Feb. 26, 2013 allantoic cavity of embryonated hens’ eggs, neomycin, polymyxin, betapropiolactone, nonylphenol ethoxylate phosphate-buffered saline, thimerosal, egg proteins, polymyxin, neomycin, betapropiolactone, nonylphenol ethoxylate
Influenza Virus Vaccine/Fluzone: Standard, High Dose, & Intradermal Sanofi Pasteur, Inc./June 2013 embryonated chicken eggs, Octylphenol Ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, formaldehyde formaldehyde, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, gelatin (standard formulation only), thimerosal (standard dosage multi-dose vial only)
16. Japanese Encephalitis Vaccine
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Japanese Encephalitis Vaccine, Inactivated, Adsorbed/Ixiaro Intercell Biomedical/Sep. 2010 Vero cells, protamine sulfate, formaldehyde, aluminum hydroxide aluminum hydroxide, formaldehyde, bovine serum albumin, host cell DNA, sodium metabisulphate, host cell proteins, protamine sulphate
Japanese Encephalitis Vaccine, Inactivated/JE-Vax Research Foundation for Microbial Diseases of Osaka University/Dec. 2005 mice (brains are innoculated with the virus), phosphate-buffered saline, formaldehyde, 40% w/v sucrose thimerosal, Sterile Water for Injection, gelatin, formaldehyde, v/v Polysorbate 80, mouse serum protein
17. Measles Vaccine
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Measles Virus Vaccine, Live/Attenuvax Merck &Co., Inc./Feb. 2006 chick embryo cell culture, buffered salt solution, vitamins, amino acides, fetal bovine serum, SPGA (sucrose, phosphate, gluatamate, human albumin), neomycin sorbitol, sodium phosphate, sucrose, sodium, chloride, hydrolyzed gelatin, human albumin, fetal bovine serum, neomycin, other buffer and media ingredients
18. Meningococcal Vaccine(meningitis)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine/MCV4-Menactra Sanofi Pasteur Inc./Nov. 2011 Mueller Hinton agar, Watson Scherp media, Mueller and Miller medium, formaldehyde, ammonium sulfate formaldehyde, sodium phosphate buffered isotonic sodium chloride solution
Meningococcal Groups C and Y and Haemophilus b Tetanus Toxoid Conjugate Vaccine/MenHibrix GlaxoSmithKline Biologicals/2012 synthetic medium, formaldehyde, sucrose, saline diluent Tris (trometamol)-HCL, sucrose, residual formaldehyde
Meningococcal (Groups A, C, Y, and W-135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine/Menveo Novartis Vaccines and Diagnostics, Inc./Mar. 2011 Franz Complete medium, formaldehyde, CY medium (contains yeast extracts and amino acids) formaldehyde
Meningococcal Polysaccharide Vaccine, Groups A, C, Y, W135 Combined/

Menomune-A/C/Y/W-135

Sanofi Pasteur Inc./

Jan. 2009

Mueller Hinton casein agar, Watson Scherp casamino acid media distilled water, thimersol, polysaccharide from serogroups A, C, Y, and w-135, mercury, lactose
19. MMR Vaccine(measles, mumps, & rubella)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Measles, Mumps, and Rubella Virus Vaccine, Live/M-M-R-II Merck and Co., Inc./Dec. 2010 chick embryo cell culture, WI-38 human diploid lung fibroblasts, Medium 199 (containing vitamins, amino acids, fetal bovine serum, SPGA (sucrose, phosphate, glutamate, recomninant human albumin), neomycin), Minimum Essential Medium (containing vitamins, amino acids, fetal bovine serum, recombinant human albumin, neomycin), sorbitol, hydrolyzed gelatin stabilizer sorbitol, sodium phosphate, sucrose, sodium chloride, hydrolyzed gelatin, recombinant human albumin, fetal bovine serum, other buffer and media ingredients, neomycin
Measles, Mumps, Rubella and Varicella Virus Vaccine Live/ProQuad, Refrigerator Stable Formulation and Frozen Formulation Merck and Co., Inc./Aug. 2011 chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, bovine serum, human albumin sucrose, hydrolized gelatin, urea, sodium chloride, sorbitol, monodium L-glutamate, sodium phosphate, human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components of MRC-5 cells (including DNA and protein), neomycin, bovine serum albumin, other buffer and media ingredients, sodium phosphate dibasic, potassium phosphate monobasic, potassium phosphate dibasic
20. Pneumococcal Vaccine(pneumonia)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein)/Prevnar Wyeth Pharmaceuticals Inc./Mar. 2009 soy peptone broth, casamino acids and yeast extract-based medium, ammonium sulfate, saccharides aluminum (as aluminum phosphate adjuvant)
Pneumococcal 13-valent Conjugate Vaccine (Diphtheria CRM197 Protein)/Prevnar 13 Wyeth Pharmaceuticals Inc./Jan. 2012 soy peptone broth, casamino acids and yeast extract-based medium, ammonium sulfate polysorbate 80, succinate buffer, aluminum (as aluminum phosphate adjuvant)
Pneumococcal Vaccine, Polyvalent/Pneumovax-23 Merck & Co., Inc./Oct. 2011 isotonic saline solution, phenol
21. Polio Vaccine
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Poliovirus Vaccine Inactivated (Monkey Kidney Cell)/IPOL Sanofi Pasteur, SA/Dec. 2005 Vero cells, Eagle MEM modified medium, newborn calf serum, M-199 (without calf serum) 2-phenoxyethanol, formaldehyde, neomycin, streptomycin, polymyxin B, residual calf serum
22. Rabies Vaccine
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Rabies Vaccine/IMOVAX Sanofi Pasteur, SA/Dec. 2005 MRC-5 cells, beta-propiolactone human albumin, neomycin sulfate, phenol red indicator, beta-propiolactone
Rabies Vaccine/RabAvert Novartis Vaccines and Diagnostics/Oct. 2006 chicken fibroblasts, synthetic cell culture medium, human albumin, polygeline (processed bovine gelatin), antibiotics, B-propiolactone, sucrose density-gradient, buffered polygeline, potassium glutamate polygeline (processed bovine gelatin), human serum albumin, potassium glutamate, sodium EDTA, bovine serum, chicken protein, neomycin, chlortracycline, amphotericin B, Water for Injection
23. Rotavirus Vaccine
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Rotavirus Vaccine, Live, Oral, Pentavalent/RotaTeq Merck & Co., Inc./Sep. 2011 chicken fibroblasts, synthetic cell culture medium (added human albumin, polygeline (processed bovine gelatin), antibiotics), B-propiolactone, sucrose density-gradient, stabilizer solution (buffered polygeline, potassium glutamate) polygeline (processed bovine gelatin), human serum albumin, potassium glutamate, sodium EDTA, bovine serum, chicken protein, neomycin, chlortetracycline, amphotericin B)
Rotavirus Vaccine, Live, Oral/Rotarix GlaxoSmithKline Biologicals/Feb. 2011 Vero cells, porcine-derived materials amino acids, dextran, Dulbecco’s Modified Eagle Medium (sodium chloride, potassium chloride, magnesium sulfate, ferric (III) nitrate, sodium phosphate, sodium pyruvate, D-glucose, concentrated vitamin solution, L-cystine, L-tyrosine, amino acids solution, L-glutamine, calcium chloride, sodium hydrogenocarbonate, phenol red), sorbitol, sucrose, calcium carbonate, sterile water, xanthan
24. Rubella Vaccine
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Rubella Virus Vaccine Live/MERUVAX II Merck & Co., Inc./Feb. 2006 WI-38 human diploid lung fibroblasts, Minimum Essential Medium (MEM; buffered salt solution (vitamins, amino acids, bovine serum), human serum albumin, neomycin), sorbitol, hydrolyzed gelatin stabilizer sorbitol, sodium phosphate, sucrose, sodium chloride, hydrolyzed gelatin, human albumin, fetal bovine serum, other buffer and media ingredients, neomycin
25. Smallpox Vaccine
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Smallpox (Vaccinia) Vaccine, Live/ACAM2000 Sanofi Pasteur Biologics Co./Aug. 2007 Vero cells, human serum albumin, sodium chloride, mannitol USP, meomycin, polymyxin B glycerin USP, phenol USP in Water for Injection USP
26. TD Vaccine(tetanus & diphtheria)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Tetanus and Diphtheria Toxoids Adsorbed For Adult Use/DECAVAC Sanofi Pasteur, Inc./Mar. 2011 Mueller and Miller medium, peptone-based medium, extract of bovine muscle tissue, formaldehyde, ammonium sulfate thimerosal, aluminum potassium sulfate adjuvant, residual formaldehyde
Tetanus and Diphtheria Toxoids Adsorbed For Adult Use/TENIVAC Sanofi Pasteur, Ltd./Dec. 2010 modified Mueller-Miller casamino acid medium without beef heart infusion, formaldehyde, ammonium sulfate, modified Mueller’s growth medium, aluminum phosphate, 2-phenoxyethanol, sodium chloride aluminum phosphate, residual formaldehyde, 2-phenoxyethanol, sodium chloride, water for injection
Tetanus and Diphtheria Toxoids, Adsorbed Mass BiologicsFeb. 2011 modified Mueller’s media (contains bovine extracts), formaldehyde, ammonium sulfate, aluminum phosphate aluminum adjuvant, residual formaldehyde, thimerosal
Tetanus Toxoid Sanofi Pasteur, Inc./Dec. 2005 peptone-based medium, formaldehyde, ammonium sulfate, physiological saline solution thimerosal, formaldehyde
Tetanus Toxoid Absorbed Sanofi Pasteur, Inc./July 2005 peptone-based medium (contains extract of bovine muscle tissue), formaldehyde, ammonium sulfate, aluminum potassium sulfate (alum) thimerosal, physiological saline solution
27. Tdap Vaccine(tetanus, diphtheria, & pertussis)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed/Adacel Sanofi Pasteur, Ltd./Dec. 2010 Stainer-Scholte medium, casamino acids, dimethyl-beta-cyclodextrin, glutaraldehyde, formaldehyde, aluminum phosphate, modified Mueller-Miller casamino acid medium without beef heart infusion, ammonium sulfate, 2-phenoxyethanol, water for injection aluminum phosphate, residual formaldehyde, residual glutaraldehyde, 2-phenoxyethanol
Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed/Boostrix GlaxoSmithKline Biologicals/Jan. 2012 modified Latham medium derived from bovine casein, Fenton medium containing bovine extract, formaldehyde, Stainer-Scholte liquid medium, glutaraldehyde, aluminum hydroxide aluminum hydroxide, sodium chloride, residual formaldehyde, polysorbate 80 (Tween 80)
28. Typhoid Vaccine
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Typhoid Vi Polysaccharide Vaccine/Typhim Vi Sanofi Pasteur SA/Dec. 2005 semi-synthetic medium without animal proteins, hexadecyltrimethylammonium bromide residual polydimethylsoloxane or fatty-acid ester-cased antifoam, isotonic phosphate buffered saline, sodium chloride, disodium phosphate, monosodium phosphate, sterile water for injection
Typhoid Vaccine Live Oral Ty21a/Vivotif Berna Biotech, Ltd./Aug. 2006 yeast extract, casein, dextrose, and galactose, sucrose, ascorbic acid, amino acids, lactose, magnesium stearate sucrose, ascorbic acid, amino acid mixture, lactose, magnesium stearate
29. Varicella Vaccine(chickenpox)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Varicella Virus Vaccine, Live/Varivax, Frozen and Refigerated Merck & Co., Inc./Aug. 2011 human embryonic lung cell cultures, embryonic guinea pig cell cultures, WI-38 human diploid cell cultures, MRC-5 human diploid cell cultures, sucrose, phosphate, glutamate, processed gelatin, urea sucrose, hydrolyzed gelatin, urea, sodium chloride, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride, residual components of MRC-5 cells (DNA, protein), neomycin, bovine calf serum, sodium phosphate monobasic, EDTA, fetal bovine serum
30. Yellow Fever Vaccine
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Yellow Fever Vaccine/YF-Vax Sanofi Pasteur, Inc./Jan. 2010 living avian leukosis virus-free (ALV-free) chicken embryos sorbitol, gelatin
31. Zoster Vaccine(shingles)
PROPER NAME/COMMERCIAL NAME MANUFACTURER/PACKAGE INSERT DATE GROWTH MEDIUMS & PROCESS INGREDIENTS VACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Zoster Vaccine, Live/Zostavax Merck & Co., Inc./June 2011 sucrose, hydrolyzed porcine gelatin, sodium chloride, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride, residual components of MRC-5 cells (DNA, protein), neomycin, bovine calf serum
  1. GLOSSARY AND DETAILS FOR INGREDIENTS
Product Possible Ingredients*
2-Phenoxyethanol 2-Phenoxyethanol is a glycol either used as a preservative in vaccines
Aluminum Аluminum is used in vaccines as an adjuvant, which helps the vaccine work more quickly and more powerfully.
Bovine casein A casein is a family of phosphoproteins commonly found in mammalian milk. 80% of the proteins in cow’s milk are casein.
Bovine serum Bovine “[s]erum is the centrifuged fluid component of either clotted or defibrinated whole blood. Bovine serum comes from blood taken from domestic cattle. Serum from other animals is also collected and processed but bovine serum is processed in the greatest volume.”“Bovine serum is a by-product of the meat industry. Bovine blood may be taken at the time of slaughter, from adult cattle, calves, very young calves or (when cows that are slaughtered are subsequently found to be pregnant) from bovine fetuses. It is also obtained from what are called ‘donor’ animals, which give blood more than once.

Blood is available from bovine fetuses only because a proportion of female animals that are slaughtered for meat for human consumption are found (often unexpectedly) to be pregnant.

Blood is available from very young calves because calves, especially males from dairy breeds, are often slaughtered soon, but not necessarily immediately, after birth because raising them will not be economically beneficial. Older animals are, of course, slaughtered for meat.

Only donor cattle are raised for the purpose of blood donation. Donor cattle are invariably kept in specialized, controlled herds. Blood is taken from these animals in a very similar way to that used for human blood donation.

Irrespective of whether blood is taken at slaughter or from donors, the age of the animal is an important consideration because it impacts the characteristics of the serum.

Bovine serum is categorised according to the age of the animal from which the blood was

collected as follows:

•’Fetal bovine serum’ comes from fetuses

•’Newborn calf serum’ comes from calves less than three weeks old

•’Calf serum’ comes from calves aged between three weeks and 12 months

•’Adult bovine serum’ comes from cattle older than 12 months

Serum processed from donor blood is termed ‘donor bovine serum’. Donor animals can be up to three years old.”

Chicken Eggs Viruses can be grown in chicken eggs before being used in vaccinations.
CMRL-1969 L-alanine, L-arginine (free base)b, L-aspartic acid, L-cysteine-HCL, L-cystine, L-glutamic acid-H20, L-gluatamine, gylcine, L-histidine (free base)b, L-hydroxyproline, L-isoleucine, L-leucine, L-lysine, L-methionine, L-phenylalanine, L-proline, L-serine, L-threonine, L-tryptophan, L-tyrosine, L-valine, p-aminobenzoic acid, ascorbic acid, d-biotin, calcium pantothenate, cholesterol, choline chloride, ethanol, folic acid, glutathione, i-inositol, menadione, nicotinamide, nicotinic acid, pyridoxal-HCL, pyridoxine-HCL, riboflavine, riboflavine-5-phosphate, sodium acetate-3H2O, thiamine-HCL, Tween 80, vitamin A acetate, vitamin D (calciferol), vitamin E (a-tocopherol phosphate), D-glucose, phenol red, sodium chloride, potassium chloride, calcium chloride, magnesium culphate heptahydrate, sodium phosphate dibasic, sodium dihydrogen phosphate, monopotassium phosphate, sodium bicarbonate, iron nitrate nonahydrate
Dulbecco’s Modified Eagle’s Serum glucose, sodium bicarbonate, L-glutamine, pyridoxine HCl, pyridocal HCl, folic acid, phenol red, HEPES (2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid), L-methionine, L-cystine, sodium phosphate mono-basic, sodium pyruvate, vitamins
Earle’s Balanced Salt Medium inorganic salts, D-glucose, phenol red, calcium, magnesium salts
Fenton Medium bovine extract
Formaldehyde Formaldehyde is used in vaccines to inactivate the virus so the person being innoculated does not contract the disease
Human albumin Human albumin is a blood plasma protein produced in the liver that, among other functions, transports hormones, fatty acids, and other compounds, and buffers pH.
Insect Cells Cabbage moth and fall armyworm cells are used to grown viruses for vaccines
Latham Medium bovine casein
MDCK (Madin-Carby canine kidney cells) cells from normal female adult Cocker Spaniel (harvested in 1958 by SH Madin and NB Darby), EMEM(EBSS) (Eagle’s Minimum Essential Medium wth Earle’s Balanced Salt Solution), glutamine, non essential amino acids, foetal bovine serum
Mouse Brains Live mice brains are innoculated with the Japanese encephalitis virus to grow the virus used in the vaccine
MRC-5 Medical Research Council 5, human diploid cells (cells containing two sets of chromosomes) derived from the normal lung tissues of a 14-week-old male fetus aborted for “psychiatric reasons” in 1966 in the United Kingdom, Earle’s Basal Medium in Earle’s balanced salt solution with bovine serum.
Mueller Hinton Agar beef extract, acid hydroysate of casein, starch, agar
Muller-Miller Medium glucose, sodium chloride, sodium phosphate dibasic, monopotassium, phosphate, magnesium sulfate hydrate, ferrous sulfate heptaphydrate, cystine hydrochloride, tyrosine hydrochloride, urasil hydrochloride, Ca-pantothenate in ethanol, thiamine in ethanol, pyridoxin-hydrochloride in ethanol, riboflavin in ethanol, biotin in ethanol, sodium hydroxide, beef heart infusion (de-fatted beef heart and distilled water), casein solution
Polysorbate 80 Also called Tween 80, Alkest 80, or Canarcel 80 (brand names). Polysorbate 80 is used as an excipient (something to basically thicken a vaccine for proper dosing) and an emulsifier (something to bond the ingredients)
Porcine gelatin Gelatin is used to protect viruses in vaccines from freeze-drying or heat and to stabilize vaccines so they stay stable
Stainer-Scholte Liquid Medium tris hydrochloride, tris base, glutamate (monosodium salt), proline, salt, monopotassium phosphate, potassium chloride, magnesium chloride, calcium chloride, ferrous sulfate, asorbic acid, niacin, glutathione
Thimerosal Thimerosal is an organomercury compound used as a preservative
Vero Cells (African Green Monkey Cells) cells derived from the kidney of a normal, adult African Green monkey in 1962 by Y. Yasumura and Y. Kawakita
WI-38 human diploid cells Winstar Institute 38, human diploid lung fibroblasts derived from the lung tissues of a female fetus aborted because the family felt they had too many children in 1964 in the United States

III. SOURCES

Acumedia Manufacturers, “Mueller Hinton Agar (7101),” http://www.neogen.com, June 2011

Atlanta Biologicals, “Earle’s Balanced Salt Solution (EBSS),” http://www.atlantabio.com, 2010

CDC, “Basics and Common Questions: Ingredients of Vaccines – Fact Sheet,” http://www.cdc.gov, Feb. 22, 2011

FDA, “Vaccines Licensed for Immunization and Distribution in the US with Supporting Documents,” http://www.fda.gov, Nov. 21, 2012

Health Protection Agency, “General Cell Collection: MDCK,” http://www.hpacultures.org.uk, 2011

G.M. Healy, S. Teleki, A.V. Seefried, M.J. Walton, and H.G. Macmorine, “Improved Chemically Defined Basal Medium (CMRL-1969) for Primary Monkey Kidney and Human Diploid Cells,” Applied and Environmental Mircobiology, http://www.aem.asm.org, 1971

International Serum Industry Association, “FAQ,” http://www.serumindustry.org/faq, 2013

Pontifical Academy on Life, “Moral Reflections on Vaccines Prepared From Cells Derived From Aborted Human Foetuses,” http://www.immunize.org/concerns/vaticandocument.htm, June 9, 2005

Rebecca Sheets, “History and Characterization of the Vero Cell Line,” http://www.fda.gov, May 12, 2000

Sigma-Aldrich, “DMEM,” http://www.sigmaaldrich.com, 2013

Alison Weiss, “The Genus Bordetella,” The Prokaryotes: A Handbook on the Biology of Bacteria,” Ed. Martin M. Dworkin, Stanley Falkow, Karl-Heinz Schleifer, and Erko Stackebrandt, 2006.

World Health Organization, “Production and Control of Tetanus Vaccine: A Training Curriculum, Module III: Principles of Tetanus Vaccine Production,” http://www.who.int, Sep. 3, 1999

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