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The most Truthful list of all Vaccines Published to date including All Official Ingredients

Amanda Mary (Mary)

We have listed vaccine ingredients (substances that appear in the final vaccine product), process ingredients (substances used to create the vaccine that may or may not appear in the final vaccine product), and growth mediums (the substances vaccines are grown in) for 31 vaccines commonly recommended by the Food & Drug Administration (FDA) and the Centers for Disease Control (CDC.) Controversial products used to make vaccines: African Green Monkey (Vero) cells, aluminum, cow products, Cocker Spaniel cells, formaldehyde, human fetal lung tissue cells, insect products, and mouse brains.

Though not listed, each vaccine contains strains of the virus being vaccinated against. Each vaccine entry links to the manufacturer’s package insert that contains information about dosage, ingredient quantity, and how the vaccine is made. Some vaccines, like influenza vaccines, are modified frequently and you may wish to consult the package inserts online and your doctor for the most current information.

  • VACCINES AND INGREDIENTS
  1. Adenovirus
  2. Anthrax
  3. BCG (tuberculosis)
  4. DT (diphtheria & tetanus)
  5. DTap (diptheria, tetanus, & pertussis)
  6. DTap-IPV (diptheria, tetanus, pertussis, & polio)
  7. DTap-HepB-IPV (diptheria, tetanus, pertussis, hepatitis B, & polio)
  8. DTap-IPV/Hib (diptheria, tetanus, pertussis, polio, & haemophilus influenzae type B)
  9. Hib (haemophilus influenzae type B)
  10. Hib/Hep B (haemophilus influenzae type B & hepatitis B)
  11. Hep A (hepatitis A)

12.Hep B (hepatitis B)

  1. Hep A/Hep B (hepatitis A & hepatitis B)
  2. HPV (human papillomavirus)
  3. Influenza 16. Japanese Encephalitis
  4. Measles
  5. Meningococcal
  6. MMR (measles, mumps, & rubella)
  7. Pneumococcal
  8. Polio
  9. Rabies
  10. Rotavirus
  11. Rubella
  12. Smallpox
  13. TD (tetanus & diphtheria)
  14. Tdap (tetanus, diphtheria, & pertussis)
  15. Typhoid
  16. Varicella (chickenpox)
  17. Yellow Fever
  18. Zoster (shingles)
1. Adenovirus Vaccine
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Adenovirus Type 4 and Type 7 Vaccine, Live, OralBarr Labs/Teva Pharmaceuticals (under contract with US Army)/Mar. 2011human-diploid fibroblast cell cultures (WI-38), Dulbecco’s Modified Eagle’s Medium, fetal bovine serum, sodium bicarbonatesucrose, D-mannose, D-fructose, dextrose, potassium phosphate, plasdone C, anhydrous lactose, micro crystalline cellulose, polacrilin potassium, magnesium stearate, cellulose acetate phthalate, alcohol, acetone, castor oil, FD&C Yellow #6 aluminum lake dye, human serum albumin
2. Anthrax Vaccine
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Anthrax Vaccine Absorbed/

Biothrax

Emergent Biosolutions/Dec. 2008amino acids, vitamins, inorganic salts and sugarsaluminum hydroxide, benzethonium chloride, formaldehyde
3. BCG Vaccine(tuberculosis)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
BCG Live/Tice BCGOrganon Teknika Corp./Feb. 2009glycerin, asparagine, citric acid, potassium phosphate, magnesium sulfate, iron ammonium citratelactose, saline
4. DT Vaccine(diphtheria & tetanus)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Diphtheria and Tetanus Toxoids AbsorbedSanofi Pasteur, Ltd./Dec. 2005peptone, bovine extract, modified Mueller and Miller mediumaluminum sulfate, formaldehyde, thimerosal (trace)
5. DTap Vaccine(diphtheria, tetanus, & pertussis)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Diphtheria and Tetanus Toxoids and Accellular Pertussis Vaccine Absorbed/DaptacelSanofi Pasteur, Ltd./July 2011Stainer-Scholte medium, modified Mueller’s growth medium, modified Mueller-Miller casamino acid medium (without beef heart infusion), casamino acids, dimethyl-beta-cyclodextrin, aluminum sulfate, aluminum phosphatealuminum phosphate, formaldehyde, glutaraldehyde, 2-Phenoxyethanol
Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Absorbed/InfanrixGlaxoSmithKline Biologicals/Nov. 2011formaldehyde, glutaraldehyde, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid mediumaluminum hydroxide, polysorbate 80, sodium chloride, formaldehyde
Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Absorbed/TripediaSanofi Pasteur, Inc./

Dec. 2005

sodium phosphate, peptone-based medium, bovine extract (US sourced), formaldehyde, ammonium sulfate, aluminum potassium sulfate, modified Mueller and Miller medium, modified Stainer-Scholte medium, isotonic sodium, chloride solution, sodium phosphatethimerosal (trace), gelatin, polysorbate 80 (Tween 80), formaldehyde, aluminum
6. DTap-IPV Vaccine(diphtheria, tetanus, pertussis, & polio)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed and Inactivated Poliovirus Vaccine/KinrixGlaxoSmithKline Biologicals/Nov. 2011formaldehyde, glutaraldehyde, aluminum hydroxide, Vero cells, calf serum, lactalbumin hydrolysate, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid mediumpolysorbate 80 (Tween 80), neomycin sulfate, polymyxin B, aluminum hydroxide, sodium chloride, formaldehyde
7. DTap-HepB-IPV Vaccine(diphtheria, tetanus, pertussis, hepatitis B, & polio)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Hepatitis B (Recombinant) and Inactivated Poliovirus Vaccine Combined/PediarixGlaxoSmithKline Biologicals/Nov. 2011formaldehyde, gluteraldehyde, aluminum hydroxide, aluminum phosphate, lactalbumin hydrolysate, calf serum, Fenton medium (containing bovine extract), modified Latham medium (derived from bovine casein), modified Stainer-Scholte liquid medium, Vero cellspolysorbate 80 (Tween 80), neomycin sulfate, polymyxin B, yeast protein, aluminum salts, sodium chloride, formaldehyde
8. DTap-IPV/Hib Vaccine(diphtheria, tetanus, pertussis, polio, & haemophilus influenzae type B)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Diphtheria and Tetanus Toxoids and Acellular Pertussis Adsorbed, Inactivated Poliovirus and Haemophilus b Conjugate (Tetanus Toxoid Conjugate) Vaccine/PentacelSanofi Pasteur, Inc./July 2011aluminum phosphate, formaldehyde, gutaraldehyde, 2-phenoxethanol, Mueller’s Growth Medium, Mueller-Miller casamino acid medium (without beef heart infusion), Stainer-Scholte medium, casamino acids, dimethyl-beta-cyclodextrin), MRC-5 cells, CMRL 1969 medium (supplemented with calf serum), ammonium sulfate, waterpolysorbate 80, bovine serum albumin, neomycin, polymyxin B sulfate, aluminum phosphate, formaldehyde, 2-phenoxethanol
9. Hib Vaccine(haemophilus influenzae type B)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate)/ActHIBSanofi Pasteur, Inc./May 2009ammonium sulfate, formalin, Modified Mueller and Miller medium, saline diluent, formaldehydesucrose, purified capsular polysaccharide
Haemophilus b Conjugate Vaccine (Tetanus Toxoid Conjugate)/HiberixGlaxoSmithKline Biologicals/Dec. 2010formaldehyde, synthetic medium, semi-synthetic mediumlactose, sodium chloride, formaldehyde, purified capsular polysaccharide
Haemophilus B Conjugate Vaccine (Meningococcal Protein Conjugate)/Liquid PedvaxHIBMerck Sharp & Dohme Corp./Dec. 2010complex fermentation media, ethanolamorphous aluminum hydroxphosphate sulfate, sodium chloride
10. Hib/Hep B Vaccine(haemophilus influenzae type B & hepatitis B)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Haemophilus b Conjugate (Meningococcal Protein Conjugate) and Hepatitis B (Recombinant) Vaccine/COMVAXMerck & Co., Inc./Dec. 2010yeast (vaccine contains no detectable yeast DNA), nicotinamide adenine dinucleotide, hemin chloride, soy peptone, dextrose, mineral salts, amino acids, formaldehyde, potassium aluminum sulfate, amorphous aluminum hydroxyphosphate sulfate, sodium boratealuminum hydroxyphosphate sulphate, sodium chloride, formaldehyde
11. Hep A Vaccine(hepatitis A)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Hepatitis A Vaccine, Inactivated/HavrixGlaxoSmithKline Biologicals/July 2011MRC-5 cells, formaldehydealuminum hydroxide, amino acid supplement, polysorbate 20, formalin, neomycin sulfate, phosphate buffered saline, residual MRC-5 cellular proteins, aminoglycoside antibiotic
Hepatitis A Vaccine, Inactivated/VAQTAMerck & Co., Inc./Dec. 2010amorphous aluminum hydroxyphosphate sulfate, formaldehyde, neomycin, MRC-5 fibroblastsbovine albumin, sodium borate, formaldehyde, non-viral proteins, sodium chloride, neomycin
12. Hep B Vaccine(hepatitis B)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Hepatitis B Vaccine (Recombinant)/Engerix-BGlaxoSmithKline Biologicals/Oct. 2011aluminum hydroxide, yeast protein, phosphate buffers, sodium chloride, disodium phosphate, dihydrate, sodium dihydrogen
Hepatitis B Vaccine (Recombinant)/RecombivaxMerck & Co., Inc./July 2011yeast protein, soy peptone, dextrose, amino acids, mineral salts, potassium aluminum sulfate, amorphous aluminum hydroxyphosphate sulfate, formaldehydeformaldehyde, yeast protein
13. Hep A/Hep B Vaccine(hepatitis A & hepatitis B)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Hepatitis A Inactivated & Hepatitis B (Recombinant) Vaccine/TwinrixGlaxoSmithKline Biologicals/Nov. 2011yeast protein, aluminum phosphate, aluminum hydroxide, amino acids, phosphate buffer, polysorbate 20, MRC-5 cells, formaldehyde, sodium chlorideneomycin sulfate, MRC-5 cell proteins, formaldehyde, yeast protein, water
14. HPV Vaccine(human papillomavirus)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Human Papillomavirus Bivalent (Types 16 and 18) Vaccine, Recombinant/CervarixGlaxoSmithKline Biologicals/July 2011vitamins, amino acids, lipids, mineral salts, aluminum (as hydroxide salt), sodium dihydrogen phosphate dehydrateinsect cell and viral protein, sodium chloride, water, aluminum hydroxide, bacterial cell protein
Human Papillomavirus Quadrivalent (Types 6, 11, 16, 18) Vaccine, Recombinant/GardasilMerck & Co., Inc./Mar. 2011yeast protein, vitamins, amino acids, mineral salts, carbohydrates, amorphous aluminum hydroxyphosphate sulfate, aluminum-containing adjuvantL-histidine, polysorbate 80, sodium borate, amorphous aluminum hydroxyphosphate sulfate adjuvant, sodium chloride, yeast protein, water
15. Influenza Vaccine(Flu)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Influenza Virus Vaccine/AfluriaCSL Limited/Apr. 2013beta-propiolactone, sodium taurodeoxycholate, allantoic fluid of embryonated chicken eggs, sucrose density agent, phosphate buffered isotonic solutionthimerosol (multi-dose vials only), monobasic sodium phosphate, dibasic sodium phosphate, monobasic potassium phosphate, potassium chloride, calcium chloride, sodium taurodeoxycholate, neomycin sulfate, polymyxin B, ovalbumin, mercury, sodium, chloride, beta-propiolacton
Influenza Virus Vaccine/AgrifluNovartis Vaccines and Diagnostics, Inc./Feb. 21, 2013kanamycin, neomycin sulfate, cetyltrimethylammonium bromide, allantoic cavity of embryonated hens’ eggsformaldehyde, egg protein, polysorbate 80, CTAB, neomycin, kanmycin
Influenza Virus VaccineFluarix/ QuadrivalentGlaxoSmithKline Biologicals/May 2013embryonated chicken eggs, sodium phosphate-buffered isotonic sodium chloride solution, sodium deoxycholate, formaldehydeoctoxynol-10 (Triton X-100), a-tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, hydrocortisone, formaldehyde, sodium deoxycholate
Influenza Vaccine/FlublokProtein Sciences Corporation/Oct. 2013HA insect cell (fall armyworm, Spodoptera frugiperda) proteins, lipids, vitamins, amino acids, mineral saltssodium chloride, monobasic sodium phosphate, dibasic sodium phosphate, polysorbate 20 (Tween 20), host cell proteins, baculovirus, Triton X-100
Influenza Virus Vaccine/FlucelvaxNovartis Vaccines and Diagnostics Limited/Feb. 2013Madin Darby Canine Kidney (MDCK) cells, B-propiolactone, cetyltrimethylammonium bromideresidual MDCK cell protein, other cell proteins, MDCK cell DNA, polysorbate 80, cetyltrimethylammonium bromide, B-propiolactone
Influenza Virus Vaccine/FluLavalID Biomedical Corporation of Quebec/2013-2014allantoic cavity of embryonated hens’ eggs, formaldehyde, sodium deocycholatephosphate-buffered saline solution, thimerosal, ovalbumin, formaldehyde, sodium deoxycholate
Influenza Vaccine Live, Intranasal/FluMist QuadrivalentMedImmune, LLC/2012-2014SPF (specific pathogen-free) eggs, stabilizing buffermonosodium glutamate, hydrolyzed porcine gelatin, arginine, sucrose, dibasic potassium phosphate, monobasic potassium phosphate, ovalbumin, gentamicin sulfate, ethylenediaminetetraacetic acid (EDTA)
Influenza Virus VaccineFluvirinNovartis Vaccines and Diagnostics Limited/Feb. 26, 2013allantoic cavity of embryonated hens’ eggs, neomycin, polymyxin, betapropiolactone, nonylphenol ethoxylatephosphate-buffered saline, thimerosal, egg proteins, polymyxin, neomycin, betapropiolactone, nonylphenol ethoxylate
Influenza Virus Vaccine/Fluzone: Standard, High Dose, & IntradermalSanofi Pasteur, Inc./June 2013embryonated chicken eggs, Octylphenol Ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, formaldehydeformaldehyde, octylphenol ethoxylate (Triton X-100), sodium phosphate-buffered isotonic sodium chloride solution, gelatin (standard formulation only), thimerosal (standard dosage multi-dose vial only)
16. Japanese Encephalitis Vaccine
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Japanese Encephalitis Vaccine, Inactivated, Adsorbed/IxiaroIntercell Biomedical/Sep. 2010Vero cells, protamine sulfate, formaldehyde, aluminum hydroxidealuminum hydroxide, formaldehyde, bovine serum albumin, host cell DNA, sodium metabisulphate, host cell proteins, protamine sulphate
Japanese Encephalitis Vaccine, Inactivated/JE-VaxResearch Foundation for Microbial Diseases of Osaka University/Dec. 2005mice (brains are innoculated with the virus), phosphate-buffered saline, formaldehyde, 40% w/v sucrosethimerosal, Sterile Water for Injection, gelatin, formaldehyde, v/v Polysorbate 80, mouse serum protein
17. Measles Vaccine
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Measles Virus Vaccine, Live/AttenuvaxMerck &Co., Inc./Feb. 2006chick embryo cell culture, buffered salt solution, vitamins, amino acides, fetal bovine serum, SPGA (sucrose, phosphate, gluatamate, human albumin), neomycinsorbitol, sodium phosphate, sucrose, sodium, chloride, hydrolyzed gelatin, human albumin, fetal bovine serum, neomycin, other buffer and media ingredients
18. Meningococcal Vaccine(meningitis)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Meningococcal Polysaccharide (Serogroups A, C, Y and W-135) Diphtheria Toxoid Conjugate Vaccine/MCV4-MenactraSanofi Pasteur Inc./Nov. 2011Mueller Hinton agar, Watson Scherp media, Mueller and Miller medium, formaldehyde, ammonium sulfateformaldehyde, sodium phosphate buffered isotonic sodium chloride solution
Meningococcal Groups C and Y and Haemophilus b Tetanus Toxoid Conjugate Vaccine/MenHibrixGlaxoSmithKline Biologicals/2012synthetic medium, formaldehyde, sucrose, saline diluentTris (trometamol)-HCL, sucrose, residual formaldehyde
Meningococcal (Groups A, C, Y, and W-135) Oligosaccharide Diphtheria CRM197 Conjugate Vaccine/MenveoNovartis Vaccines and Diagnostics, Inc./Mar. 2011Franz Complete medium, formaldehyde, CY medium (contains yeast extracts and amino acids)formaldehyde
Meningococcal Polysaccharide Vaccine, Groups A, C, Y, W135 Combined/

Menomune-A/C/Y/W-135

Sanofi Pasteur Inc./

Jan. 2009

Mueller Hinton casein agar, Watson Scherp casamino acid mediadistilled water, thimersol, polysaccharide from serogroups A, C, Y, and w-135, mercury, lactose
19. MMR Vaccine(measles, mumps, & rubella)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Measles, Mumps, and Rubella Virus Vaccine, Live/M-M-R-IIMerck and Co., Inc./Dec. 2010chick embryo cell culture, WI-38 human diploid lung fibroblasts, Medium 199 (containing vitamins, amino acids, fetal bovine serum, SPGA (sucrose, phosphate, glutamate, recomninant human albumin), neomycin), Minimum Essential Medium (containing vitamins, amino acids, fetal bovine serum, recombinant human albumin, neomycin), sorbitol, hydrolyzed gelatin stabilizersorbitol, sodium phosphate, sucrose, sodium chloride, hydrolyzed gelatin, recombinant human albumin, fetal bovine serum, other buffer and media ingredients, neomycin
Measles, Mumps, Rubella and Varicella Virus Vaccine Live/ProQuad, Refrigerator Stable Formulation and Frozen FormulationMerck and Co., Inc./Aug. 2011chick embryo cell culture, WI-38 human diploid lung fibroblasts, MRC-5 cells, bovine serum, human albuminsucrose, hydrolized gelatin, urea, sodium chloride, sorbitol, monodium L-glutamate, sodium phosphate, human albumin, sodium bicarbonate, potassium phosphate, potassium chloride, residual components of MRC-5 cells (including DNA and protein), neomycin, bovine serum albumin, other buffer and media ingredients, sodium phosphate dibasic, potassium phosphate monobasic, potassium phosphate dibasic
20. Pneumococcal Vaccine(pneumonia)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Pneumococcal 7-valent Conjugate Vaccine (Diphtheria CRM197 Protein)/PrevnarWyeth Pharmaceuticals Inc./Mar. 2009soy peptone broth, casamino acids and yeast extract-based medium, ammonium sulfate, saccharidesaluminum (as aluminum phosphate adjuvant)
Pneumococcal 13-valent Conjugate Vaccine (Diphtheria CRM197 Protein)/Prevnar 13Wyeth Pharmaceuticals Inc./Jan. 2012soy peptone broth, casamino acids and yeast extract-based medium, ammonium sulfatepolysorbate 80, succinate buffer, aluminum (as aluminum phosphate adjuvant)
Pneumococcal Vaccine, Polyvalent/Pneumovax-23Merck & Co., Inc./Oct. 2011isotonic saline solution, phenol
21. Polio Vaccine
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Poliovirus Vaccine Inactivated (Monkey Kidney Cell)/IPOLSanofi Pasteur, SA/Dec. 2005Vero cells, Eagle MEM modified medium, newborn calf serum, M-199 (without calf serum)2-phenoxyethanol, formaldehyde, neomycin, streptomycin, polymyxin B, residual calf serum
22. Rabies Vaccine
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Rabies Vaccine/IMOVAXSanofi Pasteur, SA/Dec. 2005MRC-5 cells, beta-propiolactonehuman albumin, neomycin sulfate, phenol red indicator, beta-propiolactone
Rabies Vaccine/RabAvertNovartis Vaccines and Diagnostics/Oct. 2006chicken fibroblasts, synthetic cell culture medium, human albumin, polygeline (processed bovine gelatin), antibiotics, B-propiolactone, sucrose density-gradient, buffered polygeline, potassium glutamatepolygeline (processed bovine gelatin), human serum albumin, potassium glutamate, sodium EDTA, bovine serum, chicken protein, neomycin, chlortracycline, amphotericin B, Water for Injection
23. Rotavirus Vaccine
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Rotavirus Vaccine, Live, Oral, Pentavalent/RotaTeqMerck & Co., Inc./Sep. 2011chicken fibroblasts, synthetic cell culture medium (added human albumin, polygeline (processed bovine gelatin), antibiotics), B-propiolactone, sucrose density-gradient, stabilizer solution (buffered polygeline, potassium glutamate)polygeline (processed bovine gelatin), human serum albumin, potassium glutamate, sodium EDTA, bovine serum, chicken protein, neomycin, chlortetracycline, amphotericin B)
Rotavirus Vaccine, Live, Oral/RotarixGlaxoSmithKline Biologicals/Feb. 2011Vero cells, porcine-derived materialsamino acids, dextran, Dulbecco’s Modified Eagle Medium (sodium chloride, potassium chloride, magnesium sulfate, ferric (III) nitrate, sodium phosphate, sodium pyruvate, D-glucose, concentrated vitamin solution, L-cystine, L-tyrosine, amino acids solution, L-glutamine, calcium chloride, sodium hydrogenocarbonate, phenol red), sorbitol, sucrose, calcium carbonate, sterile water, xanthan
24. Rubella Vaccine
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Rubella Virus Vaccine Live/MERUVAX IIMerck & Co., Inc./Feb. 2006WI-38 human diploid lung fibroblasts, Minimum Essential Medium (MEM; buffered salt solution (vitamins, amino acids, bovine serum), human serum albumin, neomycin), sorbitol, hydrolyzed gelatin stabilizersorbitol, sodium phosphate, sucrose, sodium chloride, hydrolyzed gelatin, human albumin, fetal bovine serum, other buffer and media ingredients, neomycin
25. Smallpox Vaccine
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Smallpox (Vaccinia) Vaccine, Live/ACAM2000Sanofi Pasteur Biologics Co./Aug. 2007Vero cells, human serum albumin, sodium chloride, mannitol USP, meomycin, polymyxin Bglycerin USP, phenol USP in Water for Injection USP
26. TD Vaccine(tetanus & diphtheria)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Tetanus and Diphtheria Toxoids Adsorbed For Adult Use/DECAVACSanofi Pasteur, Inc./Mar. 2011Mueller and Miller medium, peptone-based medium, extract of bovine muscle tissue, formaldehyde, ammonium sulfatethimerosal, aluminum potassium sulfate adjuvant, residual formaldehyde
Tetanus and Diphtheria Toxoids Adsorbed For Adult Use/TENIVACSanofi Pasteur, Ltd./Dec. 2010modified Mueller-Miller casamino acid medium without beef heart infusion, formaldehyde, ammonium sulfate, modified Mueller’s growth medium, aluminum phosphate, 2-phenoxyethanol, sodium chloridealuminum phosphate, residual formaldehyde, 2-phenoxyethanol, sodium chloride, water for injection
Tetanus and Diphtheria Toxoids, AdsorbedMass BiologicsFeb. 2011modified Mueller’s media (contains bovine extracts), formaldehyde, ammonium sulfate, aluminum phosphatealuminum adjuvant, residual formaldehyde, thimerosal
Tetanus ToxoidSanofi Pasteur, Inc./Dec. 2005peptone-based medium, formaldehyde, ammonium sulfate, physiological saline solutionthimerosal, formaldehyde
Tetanus Toxoid AbsorbedSanofi Pasteur, Inc./July 2005peptone-based medium (contains extract of bovine muscle tissue), formaldehyde, ammonium sulfate, aluminum potassium sulfate (alum)thimerosal, physiological saline solution
27. Tdap Vaccine(tetanus, diphtheria, & pertussis)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed/AdacelSanofi Pasteur, Ltd./Dec. 2010Stainer-Scholte medium, casamino acids, dimethyl-beta-cyclodextrin, glutaraldehyde, formaldehyde, aluminum phosphate, modified Mueller-Miller casamino acid medium without beef heart infusion, ammonium sulfate, 2-phenoxyethanol, water for injectionaluminum phosphate, residual formaldehyde, residual glutaraldehyde, 2-phenoxyethanol
Tetanus Toxoid, Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine, Adsorbed/BoostrixGlaxoSmithKline Biologicals/Jan. 2012modified Latham medium derived from bovine casein, Fenton medium containing bovine extract, formaldehyde, Stainer-Scholte liquid medium, glutaraldehyde, aluminum hydroxidealuminum hydroxide, sodium chloride, residual formaldehyde, polysorbate 80 (Tween 80)
28. Typhoid Vaccine
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Typhoid Vi Polysaccharide Vaccine/Typhim ViSanofi Pasteur SA/Dec. 2005semi-synthetic medium without animal proteins, hexadecyltrimethylammonium bromideresidual polydimethylsoloxane or fatty-acid ester-cased antifoam, isotonic phosphate buffered saline, sodium chloride, disodium phosphate, monosodium phosphate, sterile water for injection
Typhoid Vaccine Live Oral Ty21a/VivotifBerna Biotech, Ltd./Aug. 2006yeast extract, casein, dextrose, and galactose, sucrose, ascorbic acid, amino acids, lactose, magnesium stearatesucrose, ascorbic acid, amino acid mixture, lactose, magnesium stearate
29. Varicella Vaccine(chickenpox)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Varicella Virus Vaccine, Live/Varivax, Frozen and RefigeratedMerck & Co., Inc./Aug. 2011human embryonic lung cell cultures, embryonic guinea pig cell cultures, WI-38 human diploid cell cultures, MRC-5 human diploid cell cultures, sucrose, phosphate, glutamate, processed gelatin, ureasucrose, hydrolyzed gelatin, urea, sodium chloride, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride, residual components of MRC-5 cells (DNA, protein), neomycin, bovine calf serum, sodium phosphate monobasic, EDTA, fetal bovine serum
30. Yellow Fever Vaccine
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Yellow Fever Vaccine/YF-VaxSanofi Pasteur, Inc./Jan. 2010living avian leukosis virus-free (ALV-free) chicken embryossorbitol, gelatin
31. Zoster Vaccine(shingles)
PROPER NAME/COMMERCIAL NAMEMANUFACTURER/PACKAGE INSERT DATEGROWTH MEDIUMS & PROCESS INGREDIENTSVACCINE INGREDIENTS(not in order of quantity; see package insert for quantities)
Zoster Vaccine, Live/ZostavaxMerck & Co., Inc./June 2011sucrose, hydrolyzed porcine gelatin, sodium chloride, monosodium L-glutamate, sodium phosphate dibasic, potassium phosphate monobasic, potassium chloride, residual components of MRC-5 cells (DNA, protein), neomycin, bovine calf serum
  1. GLOSSARY AND DETAILS FOR INGREDIENTS
ProductPossible Ingredients*
2-Phenoxyethanol2-Phenoxyethanol is a glycol either used as a preservative in vaccines
AluminumАluminum is used in vaccines as an adjuvant, which helps the vaccine work more quickly and more powerfully.
Bovine caseinA casein is a family of phosphoproteins commonly found in mammalian milk. 80% of the proteins in cow’s milk are casein.
Bovine serumBovine “[s]erum is the centrifuged fluid component of either clotted or defibrinated whole blood. Bovine serum comes from blood taken from domestic cattle. Serum from other animals is also collected and processed but bovine serum is processed in the greatest volume.”“Bovine serum is a by-product of the meat industry. Bovine blood may be taken at the time of slaughter, from adult cattle, calves, very young calves or (when cows that are slaughtered are subsequently found to be pregnant) from bovine fetuses. It is also obtained from what are called ‘donor’ animals, which give blood more than once.

Blood is available from bovine fetuses only because a proportion of female animals that are slaughtered for meat for human consumption are found (often unexpectedly) to be pregnant.

Blood is available from very young calves because calves, especially males from dairy breeds, are often slaughtered soon, but not necessarily immediately, after birth because raising them will not be economically beneficial. Older animals are, of course, slaughtered for meat.

Only donor cattle are raised for the purpose of blood donation. Donor cattle are invariably kept in specialized, controlled herds. Blood is taken from these animals in a very similar way to that used for human blood donation.

Irrespective of whether blood is taken at slaughter or from donors, the age of the animal is an important consideration because it impacts the characteristics of the serum.

Bovine serum is categorised according to the age of the animal from which the blood was

collected as follows:

•’Fetal bovine serum’ comes from fetuses

•’Newborn calf serum’ comes from calves less than three weeks old

•’Calf serum’ comes from calves aged between three weeks and 12 months

•’Adult bovine serum’ comes from cattle older than 12 months

Serum processed from donor blood is termed ‘donor bovine serum’. Donor animals can be up to three years old.”

Chicken EggsViruses can be grown in chicken eggs before being used in vaccinations.
CMRL-1969L-alanine, L-arginine (free base)b, L-aspartic acid, L-cysteine-HCL, L-cystine, L-glutamic acid-H20, L-gluatamine, gylcine, L-histidine (free base)b, L-hydroxyproline, L-isoleucine, L-leucine, L-lysine, L-methionine, L-phenylalanine, L-proline, L-serine, L-threonine, L-tryptophan, L-tyrosine, L-valine, p-aminobenzoic acid, ascorbic acid, d-biotin, calcium pantothenate, cholesterol, choline chloride, ethanol, folic acid, glutathione, i-inositol, menadione, nicotinamide, nicotinic acid, pyridoxal-HCL, pyridoxine-HCL, riboflavine, riboflavine-5-phosphate, sodium acetate-3H2O, thiamine-HCL, Tween 80, vitamin A acetate, vitamin D (calciferol), vitamin E (a-tocopherol phosphate), D-glucose, phenol red, sodium chloride, potassium chloride, calcium chloride, magnesium culphate heptahydrate, sodium phosphate dibasic, sodium dihydrogen phosphate, monopotassium phosphate, sodium bicarbonate, iron nitrate nonahydrate
Dulbecco’s Modified Eagle’s Serumglucose, sodium bicarbonate, L-glutamine, pyridoxine HCl, pyridocal HCl, folic acid, phenol red, HEPES (2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid), L-methionine, L-cystine, sodium phosphate mono-basic, sodium pyruvate, vitamins
Earle’s Balanced Salt Mediuminorganic salts, D-glucose, phenol red, calcium, magnesium salts
Fenton Mediumbovine extract
FormaldehydeFormaldehyde is used in vaccines to inactivate the virus so the person being innoculated does not contract the disease
Human albuminHuman albumin is a blood plasma protein produced in the liver that, among other functions, transports hormones, fatty acids, and other compounds, and buffers pH.
Insect CellsCabbage moth and fall armyworm cells are used to grown viruses for vaccines
Latham Mediumbovine casein
MDCK (Madin-Carby canine kidney cells)cells from normal female adult Cocker Spaniel (harvested in 1958 by SH Madin and NB Darby), EMEM(EBSS) (Eagle’s Minimum Essential Medium wth Earle’s Balanced Salt Solution), glutamine, non essential amino acids, foetal bovine serum
Mouse BrainsLive mice brains are innoculated with the Japanese encephalitis virus to grow the virus used in the vaccine
MRC-5Medical Research Council 5, human diploid cells (cells containing two sets of chromosomes) derived from the normal lung tissues of a 14-week-old male fetus aborted for “psychiatric reasons” in 1966 in the United Kingdom, Earle’s Basal Medium in Earle’s balanced salt solution with bovine serum.
Mueller Hinton Agarbeef extract, acid hydroysate of casein, starch, agar
Muller-Miller Mediumglucose, sodium chloride, sodium phosphate dibasic, monopotassium, phosphate, magnesium sulfate hydrate, ferrous sulfate heptaphydrate, cystine hydrochloride, tyrosine hydrochloride, urasil hydrochloride, Ca-pantothenate in ethanol, thiamine in ethanol, pyridoxin-hydrochloride in ethanol, riboflavin in ethanol, biotin in ethanol, sodium hydroxide, beef heart infusion (de-fatted beef heart and distilled water), casein solution
Polysorbate 80Also called Tween 80, Alkest 80, or Canarcel 80 (brand names). Polysorbate 80 is used as an excipient (something to basically thicken a vaccine for proper dosing) and an emulsifier (something to bond the ingredients)
Porcine gelatinGelatin is used to protect viruses in vaccines from freeze-drying or heat and to stabilize vaccines so they stay stable
Stainer-Scholte Liquid Mediumtris hydrochloride, tris base, glutamate (monosodium salt), proline, salt, monopotassium phosphate, potassium chloride, magnesium chloride, calcium chloride, ferrous sulfate, asorbic acid, niacin, glutathione
ThimerosalThimerosal is an organomercury compound used as a preservative
Vero Cells (African Green Monkey Cells)cells derived from the kidney of a normal, adult African Green monkey in 1962 by Y. Yasumura and Y. Kawakita
WI-38 human diploid cellsWinstar Institute 38, human diploid lung fibroblasts derived from the lung tissues of a female fetus aborted because the family felt they had too many children in 1964 in the United States

III. SOURCES

Acumedia Manufacturers, “Mueller Hinton Agar (7101),” http://www.neogen.com, June 2011

Atlanta Biologicals, “Earle’s Balanced Salt Solution (EBSS),” http://www.atlantabio.com, 2010

CDC, “Basics and Common Questions: Ingredients of Vaccines – Fact Sheet,” http://www.cdc.gov, Feb. 22, 2011

FDA, “Vaccines Licensed for Immunization and Distribution in the US with Supporting Documents,” http://www.fda.gov, Nov. 21, 2012

Health Protection Agency, “General Cell Collection: MDCK,” http://www.hpacultures.org.uk, 2011

G.M. Healy, S. Teleki, A.V. Seefried, M.J. Walton, and H.G. Macmorine, “Improved Chemically Defined Basal Medium (CMRL-1969) for Primary Monkey Kidney and Human Diploid Cells,” Applied and Environmental Mircobiology, http://www.aem.asm.org, 1971

International Serum Industry Association, “FAQ,” http://www.serumindustry.org/faq, 2013

Pontifical Academy on Life, “Moral Reflections on Vaccines Prepared From Cells Derived From Aborted Human Foetuses,” http://www.immunize.org/concerns/vaticandocument.htm, June 9, 2005

Rebecca Sheets, “History and Characterization of the Vero Cell Line,” http://www.fda.gov, May 12, 2000

Sigma-Aldrich, “DMEM,” http://www.sigmaaldrich.com, 2013

Alison Weiss, “The Genus Bordetella,” The Prokaryotes: A Handbook on the Biology of Bacteria,” Ed. Martin M. Dworkin, Stanley Falkow, Karl-Heinz Schleifer, and Erko Stackebrandt, 2006.

World Health Organization, “Production and Control of Tetanus Vaccine: A Training Curriculum, Module III: Principles of Tetanus Vaccine Production,” http://www.who.int, Sep. 3, 1999

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